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ARTICLE - COVID-19 gastrointestinal symptoms and attenuation of the immune response to SARS-CoV-2

Gastroenterology Journal (Gastro Journal)

Major questions remain regarding how SARS-CoV-2 behaves in the GI tract, including the viability of the SARS-CoV-2 viral envelope in the harsh biochemical environment of the GI lumen6 . Other questions include interaction of the virus with disease states that modify susceptibility including potential infection via susceptible metaplastic cells in the esophagus, thus bypassing the gastric acidity or bile emulsification in those patients with Barrett’s esophagus

ARTICLE - FACTORS ASSOCIATED WITH COVID-19 SEVERITY AMONG PATIENTS WITH CANCER

European Society of Medical Oncology (ESMO)

These findings can inform novel translational research, clinical trial designs, and clinical decision-making for cancer patients with COVID-19. The CCC19 researchers plan further investigation into healthcare disparities, outcomes for specific cancer subtypes, and impact of particular anticancer therapies.

ARTICLE - Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors

Gastroenterology Journal (Gastro Journal)

Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early-life.

ARTICLE - The relationship between gastrointestinal cancers and the microbiota

The Lancet (LG)

The contribution of the microbiota to disease progression and treatment efficacy is often neglected when determining who is at the highest risk of developing gastrointestinal cancers or designing treatment strategies for patients. We reviewed the current literature on the effect of the human microbiota on cancer risk, prognosis, and treatment efficacy. We highlight emerging research that seeks to identify microbial signatures as biomarkers for various gastrointestinal cancers, and discuss how we could harness knowledge of the microbiome to detect, prevent, and treat these cancers. Finally, we outline further research needed in the field of gastrointestinal cancers and the microbiota, and describe the efforts required to increase the accuracy and reproducibility of data linking the microbiome to cancer.

ARTICLE - Once-Weekly Semaglutide in Adults with Overweight or Obesity

The New England Journal of Medicine (NEJM Gastro)

Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed.

ARTICLE - Bariatric Surgery Reduces Cancer Risk in Adults with Nonalcoholic Fatty Liver Disease and Severe Obesity

Gastroenterology Journal (Gastro Journal)

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and increased risk of cancer. The impacts of bariatric surgery on cancer risk in NAFLD patients are unknown. We investigated the effect of bariatric surgery on cancer risk in patients with NAFLD and severe obesity using the Marketscan database.

ARTICLE - Risk factors for rebleeding in Crohn’s disease patients with acute severe lower gastrointestinal bleeding: with special reference to the role of anti‐TNF therapy

Journal of Gastroenterology and Hepatology (JGH)

Acute severe lower gastrointestinal bleeding (LGIB) in patients with Crohn’s disease (CD) is uncommon; however, it is a potentially life‐threatening complication and its recurrence is common. We thus aimed to identify the predictors for rebleeding in CD patients with acute severe LGIB and particularly focused on whether anti‐tumor necrosis factor (TNF) therapy lowers the risk of rebleeding compared with conventional medical therapy (CMT) or surgery.

ARTICLE - RELATIONSHIP BETWEEN GASTRIC EMPTYING RATE AND SIMULTANEOUSLY ASSESSED SYMPTOMS IN FUNCTIONAL DYSPEPSIA

Clinical Gastroenterology and Hepatology (CGH)

The relevance of gastric emptying (GE) rate to symptom generation in functional dyspepsia and idiopathic gastroparesis is a matter of controversy. We aimed to evaluate the relationship between symptom severity and GE when simultaneously assessed, avoiding biases of recall symptom severity questionnaires and single-time-point GE measurements.

ARTICLE - Expanding the diagnostic toolkit of Wilson disease with ATP7B peptides

Gastroenterology Journal (Gastro Journal)

adopt a new approach to the diagnosis of WD based on the quantification of ATP7B protein concentration derived from measurement of two surrogate peptides in patient dried blood spot samples, as direct evidence of WD diagnosis.

ARTICLE - Resolution of loculated chylous ascites using intra peritoneal fibrinolytic therapy

Journal of Hepatology (JoH)

Therapeutic paracentesis is the preferred therapy for symptom relief in patients with large‐volume ascites. However, when the ascites becomes loculated, removal of sufficient fluid to provide symptomatic relief may not be achieved. Loculation, rare without previous abdominal surgery, is typically associated with malignancy, post‐surgical adhesions, bowel perforation, and chylous ascites.

ARTICLE - Yttrium‐90 Radioembolization for the Treatment of Solitary, Unresectable Hepatocellular Carcinoma: The LEGACY Study

Journal of Hepatology (JoH)

Locoregional therapies, including yttrium‐90 (90Y) radioembolization, play an important role in the treatment of unresectable hepatocellular carcinoma (HCC). The aim of the LEGACY study was to evaluate objective response rate (ORR) and duration of response (DoR) in patients with solitary unresectable HCC treated with 90Y glass microspheres.

RECOMMANDATION - SFEDNEWS N°688 - 12 MARS 2021 : « VACCINATION EN ENDOSCOPIE DIGESTIVE : POSITION DE LA SFED ET DE L'ESGE À PROPOS DE LA VACCINATION DES ÉQUIPES D'ENDOSCOPIE DIGESTIVE »

Société Française d'Endoscopie Digestive (SFED)

Néanmoins, l'ESGE et la SFED recommandent très fortement la protection du personnel soignant des unités d'endoscopie par les vaccins approuvés par l'EMA et disponibles dans les établissements de santé. La vaccination réduit la transmission malade-soignant mais aussi soignant-soignant. Cependant, le manque de données doit nous faire garder les mêmes règles de protection pour l'instant en endoscopie, aussi bien vis-à-vis des malades (PCR systématique datant de moins de 72 heures avant toute endoscopie digestive, interrogatoire systématique avant l'entrée dans le centre d'endoscopie digestive, port de masque chirurgical pour les patients…)

INFORMATION MEDICAMENT - Anticorps monoclonaux : l’ANSM permet l’utilisation en accès précoce de deux bithérapies contre la COVID-19

Agence nationale de sécurité du médicament et des produits de santé (ANSM)

L’ANSM permet l’utilisation en accès précoce de deux bithérapies d’anticorps monoclonaux dans un cadre sécurisé pour traiter les patients adultes à risque de forme grave de la COVID-19 dès l'apparition des symptômes. Il s’agit des bithérapies casirivimab/imdevimab du laboratoire Roche et bamlanivimab/etesevimab du laboratoire Lilly France.

INFORMATION MEDICAMENT - Point de situation sur la surveillance des vaccins contre la COVID-19

Agence nationale de sécurité du médicament et des produits de santé (ANSM)

Dans le cadre de la surveillance renforcée des vaccins utilisés contre la Covid-19, une enquête de pharmacovigilance est mise en place pour surveiller en temps réel le profil de sécurité des vaccins disponibles en France à partir des déclarations réalisées par les professionnels de santé, les personnes vaccinées ou leur entourage. Les résultats de cette évaluation et de ce suivi ont été présentés et discutés collégialement lors du comité de suivi hebdomadaire de l’ANSM avec le réseau français des CRPV du 11 mars 2021, afin d’identifier des signaux potentiels et d’envisager les mesures à prendre.

RECOMMANDATION - BRAZILIAN SOCIETY OF HEPATOLOGY AND BRAZILIAN COLLEGE OF RADIOLOGY PRACTICE GUIDANCE FOR THE USE OF ELASTOGRAPHY IN LIVER DISEASES

Annals of Hepatology (AoH)

Several tools for assessing fibrosis and steatosis in chronic liver diseases (CLD), particularly hepatitis B and C, non-alcoholic fatty liver disease (NAFLD), and alcoholic liver disease (ALD), have been proposed as non-invasive and cost-effective alternatives to liver biopsy. Due to its overall accuracy, elastography has been viewed as the gold-standard non-invasive method to replace histological evaluation.

RECOMMANDATION - AGA Clinical Practice Update on Evaluation and Management of Early Complications After Bariatric/Metabolic Surgery: Expert Review

Clinical Gastroenterology and Hepatology (CGH)

Endoscopic techniques are paramount in the identification and management of complications after bariatric/metabolic surgery, though collaboration with other specialties is obligatory. Unfortunately, the evaluation and treatment algorithms are not standardized and there is a paucity of high-quality prospective studies to provide clarity regarding the best approach. The purpose of this clinical practice update is to apprise the clinician with respect to the endoscopic evaluation and management of patients with early (<90 days) complications after undergoing bariatric/metabolic surgery.

ARTICLE - What is the real impact of corticosteroids in the contemporary treatment of Crohn’s disease?

Clinical Gastroenterology and Hepatology (CGH)

In the light of current knowledge, it seems clear that we are overusing steroids in the maintenance treatment of IBD patients. The question raised with the recent findings of Faleck et al. is: are we overusing steroids during induction as well

ARTICLE - Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

Gastroenterology Journal (Gastro Journal)

Celiac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten. Despite adhering to a gluten-free diet (the only management option available to patients with CeD), many patients continue to experience symptoms and intestinal injury.

ARTICLE - What can we do to tackle anxiety and depression in patients with inflammatory bowel disease?

The Lancet (LG)

The mental health of patients with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a growing concern, with data pointing not only to the high prevalence of psychiatric comorbidity 1 but also to the negative effects of depression and anxiety on disease outcomes.

ARTICLE - Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis

The Lancet (LG)

Inflammatory bowel disease (IBD) is a lifelong condition with no cure. Patients with IBD might experience symptoms of common mental disorders such as anxiety and depression because of bidirectional communication via the gut–brain axis and chronicity of symptoms, and because of impaired quality of life and reduced social functioning

ARTICLE - Modified endoscopic radial incision and cutting method (M-RIC) for the treatment of refractory esophageal stricture

European Association for Endoscopic Surgery (EAES)

Refractory esophageal stricture is difficult to deal with. Some refractory stricture shows little response to now-existing endoscopic techniques. We assessed the efficacy of modified endoscopic radial incision and cutting method (M-RIC) for the treatment of refractory esophageal stricture.

INFORMATION Stratégie de vaccination contre le Sars-Cov-2 - Actualisation des facteurs de risque de formes graves de la Covid-19 et des recommandations sur la stratégie de priorisation des populations à vacciner

02/03/2021

Haute Autorité de Santé (HAS)

La HAS, en s’appuyant sur la Commission technique des vaccinations, a procédé à l’actualisation de la revue de la littérature des facteurs de risque de formes graves et de décès associés à la Covid-19 et des facteurs de risque d’exposition lui permettant de fonder les choix de personnes à vacciner en priorité compte tenu de leur risque.

RECOMMANDATION Stratégie de vaccination contre le SARS-CoV-2 - Extension des compétences vaccinales des professionnels de santé

02/03/2021

Haute Autorité de Santé (HAS)

Suite à une saisine de la Direction générale de la santé, la Haute Autorité de santé (HAS) et sa Commission Technique des vaccinations (CTV) émettent des recommandations établissant l’intérêt et les conditions d’une extension des compétences en matière de vaccination contre la covid-19, des infirmiers, des sages-femmes et des pharmaciens ainsi que les formations et/ou les pré-requis nécessaires à la pratique de ces vaccinations.

INFORMATION AYVAKYT

11/03/2021

Haute Autorité de Santé (HAS)

Avis favorable au remboursement en monothérapie pour le traitement des patients adultes atteints de tumeurs stromales gastro-intestinales (GIST) non résécables ou métastatiques porteuses de la mutation D842V du récepteur alpha du facteur de croissance dérivé des plaquettes (PDGFRA).

INFORMATION LYNPARZA

05/03/2021

Haute Autorité de Santé (HAS)

La spécialité LYNPARZA (olaparib) est destinée à traiter une maladie grave et rare. Il existe des comparateurs pertinents, au regard des connaissances médicales avérées, à LYNPARZA (olaparib), dans l’indication considérée, à savoir après progression suite à un traitement antérieur incluant une hormonothérapie de nouvelle génération (HTNG).